Best Arginine for Heart
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Last reviewed May 2026
Clinical dose: 2000–6000 mg
Why Arginine for Heart
Arginine plays a supporting role in heart. L-Arginine is a conditionally essential amino acid and a precursor to nitric oxide (NO), which supports vasodilation and blood flow. Used for cardiovascular support, exercise performance, and recovery.
What dose to look for
Clinical studies typically use 2000–6000 mg of arginine. Common supplemental range for cardiovascular and exercise performance benefits. Doses up to 9 g/day have been used in clinical studies. Products below this range may not deliver meaningful results.
What the research says
Arginine has moderate clinical evidence for heart benefits. Multiple trials on nitric oxide production and blood flow, but oral bioavailability is limited Learn more
Clinical research on L-Arginine
LOW — Nitric oxide precursor but poor oral bioavailability limits clinical utility · 3,000–6,000 mg/day
- •2011 meta-analysis of 11 RCTs found L-arginine reduced systolic BP by 5.4 mmHg and diastolic BP by 2.7 mmHg, but trial quality was low and durations were short. PubMed
- •Largely supplanted by L-citrulline in clinical practice. Oral arginine has high first-pass metabolism — approximately 40% is degraded by gut arginase before reaching systemic circulation.
- •Caution: the 2006 VINTAGE MI trial was stopped early because L-arginine supplementation post-MI was associated with increased mortality. Contraindicated after heart attack. PubMed