Best PQQ for Longevity
Top 2 products ranked
Last reviewed May 2026
Clinical dose: 10–20 mg
Why PQQ for Longevity
PQQ plays a supporting role in longevity. PQQ is a redox cofactor that supports mitochondrial biogenesis through PGC-1alpha activation. A 2012 RCT (17 adults, 20 mg/day BioPQQ for 8 weeks) showed significant improvements in vigor and fatigue measures as well as improvements in sleep quality and cortisol awakening response.
What dose to look for
Clinical studies typically use 10–20 mg of pqq. Most human studies use 10–20 mg/day of PQQ disodium salt (BioPQQ). Some studies combine with CoQ10. Products below this range may not deliver meaningful results.
What the research says
PQQ has limited clinical evidence for longevity benefits. Only a few small human studies (largest n=17); strong preclinical data but limited clinical evidence Learn more
