About Chlorophyllin
A water-soluble semi-synthetic derivative of chlorophyll. The strongest evidence comes from a landmark RCT (Egner et al., 2001, PNAS; n=180) showing 55% reduction in urinary aflatoxin biomarkers at 300 mg/day — relevant to detoxification and chemoprevention in aflatoxin-exposed populations. Older trials support deodorizing effects for body/fecal odor in geriatric populations. FDA GRAS as a food colorant. Natural chlorophyll (fat-soluble) is a different compound with poor absorption and should not be equated with chlorophyllin. Chlorella is a whole algae and not equivalent. Generally well tolerated; may cause green discoloration of urine/stool.
What Chlorophyllin supports
- May support detoxification pathways
- Internal deodorizing properties
How much Chlorophyllin to take
The RDA prevents deficiency. The effective range is what clinical trials used to actually move the outcome.
Effective
100–300
mg
100 mg 1–3x daily used in clinical trials. The Egner 2001 RCT used 100 mg TID (300 mg/day).
Clinical evidence
Limited clinical evidence. One strong RCT (Egner 2001) for aflatoxin chemoprevention; 3–5 total human trials; no meta-analyses
Reference