About DHEA
DHEA is a precursor hormone produced by the adrenal glands that declines with age. Meta-analysis (42 publications, 55 arms) shows significant testosterone increase (WMD: 28 ng/dL). More pronounced effects in women, healthy subjects, and at >50 mg/day. Postmenopausal women show elevated estradiol at 50 mg/day. Benefits for adrenal insufficiency well-established. Mixed evidence for body composition, bone health, sexual function, and quality of life in general population. No established RDA/UL.
What DHEA supports
- Significantly increases testosterone levels (meta-analysis of 42 publications)
- May reduce fat mass in elderly men (meta-analysis)
How much DHEA to take
Clinical studies typically use 25–100 mg of DHEA. Most RCTs use 50 mg/day. Meta-analysis of 42 publications shows significant hormone increases at ≥50 mg/day. 25 mg used in some adrenal insufficiency studies. Doses above 100 mg/day are not well-studied and may increase side effect risk.
- Effective range
- 25–100 mg
Clinical evidence
Moderate clinical evidence. Meta-analysis of 42 publications shows significant hormone changes, especially in women and elderly
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