About GABA
GABA is the primary inhibitory neurotransmitter in the brain. Whether supplemental GABA crosses the blood-brain barrier is debated. Some evidence suggests it may act through the enteric nervous system via the vagus nerve. Mixed results in placebo-controlled trials for stress and sleep. No established RDA/UL.
What GABA supports
- May promote relaxation and reduce stress
- May support sleep onset
How much GABA to take
Clinical studies typically use 100–300 mg of GABA. Common supplemental range; PharmaGABA (fermented) may have better bioavailability than synthetic forms.
- Effective range
- 100–300 mg
Clinical evidence
Limited clinical evidence. Debated whether it crosses the blood-brain barrier; mixed results in placebo-controlled trials
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