About HMRlignan
HMRlignan (7-hydroxymatairesinol) is a plant lignan isolated from Norway spruce (Picea abies) knots. Gut bacteria convert it to enterolactone, a mammalian lignan with weak estrogenic and antioxidant properties. Udani et al. (2013, J Med Food, RCT, n=44 postmenopausal women) showed 36 mg/day for 60 days reduced hot flash severity. Observational studies link higher enterolactone levels to lower cardiovascular risk (Vanharanta et al. 1999, Kitts et al. 1999), but these are epidemiological, not interventional. Very limited RCT data beyond the single hot flash trial.
What HMRlignan supports
- Reduced hot flash severity in one RCT (postmenopausal women)
- Antioxidant properties via enterolactone metabolite
How much HMRlignan to take
The RDA prevents deficiency. The effective range is what clinical trials used to actually move the outcome.
Effective
36–72
mg
Udani et al. (2013) used 36 mg/day HMRlignan in postmenopausal women. Higher doses (72 mg/day) used in some protocols. Converted by gut bacteria to enterolactone.
Clinical evidence
Limited clinical evidence. One small RCT (n=44) for hot flash severity; observational links to cardiovascular health. Very limited interventional data.
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