BioStacks

Carnitine

Amino Acid
Ca
Strong Evidence

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About Carnitine

L-Carnitine is essential for mitochondrial fatty acid transport and energy metabolism. A 2020 meta-analysis (37 RCTs) found L-carnitine supplementation significantly reduced body weight and BMI. A 2013 meta-analysis (13 RCTs) showed reduced all-cause mortality and ventricular arrhythmias in acute myocardial infarction patients. Acetyl-L-carnitine (ALCAR) is the preferred form for cognitive support — a meta-analysis showed improvements in mild cognitive impairment and early Alzheimer's. L-carnitine tartrate is preferred for exercise performance. Endogenous synthesis requires lysine, methionine, and vitamin C.

What Carnitine supports

  • Supports mitochondrial energy production and fat metabolism
  • May reduce cardiovascular mortality post-MI
  • ALCAR form supports cognitive function in age-related decline
  • May support exercise recovery and reduce muscle damage

How much Carnitine to take

Clinical studies typically use 500–2000 mg of Carnitine. Most RCTs use 1–2 g/day of L-carnitine or ALCAR. Exercise studies use 1.5–2 g/day. Cognitive ALCAR studies use 1.5–3 g/day.

Effective range
500–2000 mg

Clinical evidence

Strong clinical evidence. Meta-analyses of 37+ trials support benefits for weight, cardiovascular health, and cognitive function

Examine.com
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