Licorice Root Extract
Dosing Guide
RDA
None
Effective
150–500 mg
Upper Limit
None
Standard extract doses of 150–500 mg/day. DGL form typically dosed at 380 mg chewed before meals, 2-3x/day (~760–1140 mg/day). Glycyrrhizin intake should stay below 100 mg/day (EU/EFSA threshold) to avoid hypertension and hypokalemia.
About Licorice Root Extract
Contains glycyrrhizin, glabridin, and liquiritigenin as key bioactives. A few small, older trials (1970s-80s) suggest DGL form may benefit peptic ulcer symptoms and functional dyspepsia, but study quality is poor and no modern well-powered RCTs exist. Anti-viral and anti-inflammatory effects are primarily demonstrated in vitro and animal models — oral bioavailability of glycyrrhizin is limited. Carries dose-dependent risks of pseudoaldosteronism (hypertension, edema, hypokalemia). The DGL form removes most glycyrrhizin and is considered safer for long-term use.