About Magnesium
Cofactor in over 300 enzymatic reactions including energy production, protein synthesis, and nervous system regulation. Magnesium glycinate is preferred for calm and sleep support with minimal GI effects, threonate (Magtein) crosses the blood-brain barrier for cognitive benefits, and citrate has a mild laxative effect useful for constipation. Oxide is cheap but poorly absorbed (~4%). Subclinical deficiency is common—estimated to affect over 50% of the population—because serum levels don't reflect intracellular stores.
What Magnesium supports
- Supports energy production and reduces fatigue
- Supports muscle and nerve function
- Supports heart rhythm and bone health
How much Magnesium to take
Clinical studies typically use 100–400 mg of Magnesium. Common clinical supplemental range; RDA for total intake is 310-420 mg.
- RDA
- 200 mg
- Upper limit (UL)
- 350 mg
- Effective range
- 100–400 mg
Forms of Magnesium compared
- Magnesium glycinatePremiumChelated, calming, well-tolerated even at 400+ mg.
- Magnesium tauratePremiumGlycine-bound; favored for cardiovascular support.
- Magnesium L-threonate (Magtein)PremiumCrosses the blood-brain barrier — studied for cognition.
- Magnesium citrateStandardWell-absorbed. Causes loose stools above ~400 mg — by design.
- Magnesium malateStandardDecent absorption; favored for muscle and energy support.
- Magnesium chlorideBudgetDecent absorption; common in liquid magnesium with a salty taste.
- Magnesium aspartateBudgetModest absorption; aspartate is excitatory at high doses — not for sensitive users.
- Magnesium oxideBudgetLow absorption (~4%)
- Magnesium stearateBudgetFiller, not a bioavailable form
Clinical evidence
Strong clinical evidence. Meta-analyses confirm benefits for blood pressure, sleep, and glucose; ~50% of adults may be subclinically deficient
NIH Fact Sheet