About Sesamin
Sesame lignans (primarily sesamin and sesamolin) are bioactive compounds that inhibit delta-5 desaturase and support gamma-tocopherol levels by slowing its hepatic metabolism. Research shows antioxidant, anti-inflammatory, and lipid-lowering properties. Commonly used alongside vitamin E supplements to boost gamma-tocopherol retention. Animal studies show hepatoprotective and blood pressure–lowering effects; human data is limited but growing. No established RDA/UL.
What Sesamin supports
- May support healthy cholesterol and blood pressure levels
- Enhances gamma-tocopherol (vitamin E) retention and antioxidant activity
- Hepatoprotective properties — supports liver antioxidant defenses
How much Sesamin to take
The RDA prevents deficiency. The effective range is what clinical trials used to actually move the outcome.
Effective
10–50
mg
Commonly dosed at 10–50 mg per serving. Often paired with vitamin E or gamma-tocopherol to enhance their bioavailability.
Clinical evidence
Moderate clinical evidence. Several studies on antioxidant and lipid effects, but human clinical data is still limited
Examine.com