About Sulforaphane
Sulforaphane is an isothiocyanate from cruciferous vegetables (primarily broccoli sprouts) that activates the Nrf2 antioxidant pathway. A comprehensive review identified 84 clinical trials (39 published). Meta-analyses show benefits for autism spectrum disorder symptoms (irritability, hyperactivity) and cardiometabolic markers (blood pressure reduction). Type 2 diabetes trials showed glycemic improvements. However, ~50% of trials remain unpublished, sample sizes are small, and outcomes are inconsistent across conditions. Promising but evidence is still maturing.
What Sulforaphane supports
- Activates Nrf2 antioxidant pathway — multiple RCTs across various conditions
- May improve autism symptoms (meta-analysis: irritability and hyperactivity)
- Emerging cardiometabolic benefits including blood pressure reduction (meta-analysis)
How much Sulforaphane to take
Clinical studies typically use 1–9 mg of Sulforaphane. No established ideal dose. Examine estimates 1.1–9.1 mg/day for a 150–250 lb person based on allometric scaling from animal studies (0.1–0.5 mg/kg in rats). Many supplement brands use higher doses (10–100 mg) but these are typically glucoraphanin-equivalent, not pure sulforaphane.
- Effective range
- 1–9 mg
Clinical evidence
Moderate clinical evidence. 84 clinical trials identified but ~50% unpublished; small sample sizes and inconsistent outcomes
Examine.com