About Sulforaphane
Sulforaphane is an isothiocyanate from cruciferous vegetables (primarily broccoli sprouts) that activates the Nrf2 antioxidant pathway. A comprehensive review identified 84 clinical trials (39 published). Meta-analyses show benefits for autism spectrum disorder symptoms (irritability, hyperactivity) and cardiometabolic markers (blood pressure reduction). Type 2 diabetes trials showed glycemic improvements. However, ~50% of trials remain unpublished, sample sizes are small, and outcomes are inconsistent across conditions. Promising but evidence is still maturing.
What Sulforaphane supports
- Activates Nrf2 antioxidant pathway — multiple RCTs across various conditions
- May improve autism symptoms (meta-analysis: irritability and hyperactivity)
- Emerging cardiometabolic benefits including blood pressure reduction (meta-analysis)
How much Sulforaphane to take
The RDA prevents deficiency. The effective range is what clinical trials used to actually move the outcome.
Effective
1–9
mg
No established ideal dose. Examine estimates 1.1–9.1 mg/day for a 150–250 lb person based on allometric scaling from animal studies (0.1–0.5 mg/kg in rats). Many supplement brands use higher doses (10–100 mg) but these are typically glucoraphanin-equivalent, not pure sulforaphane.
Clinical evidence
Moderate clinical evidence. 84 clinical trials identified but ~50% unpublished; small sample sizes and inconsistent outcomes
Examine.com