Despite the name, this product's headline hair and skin ingredients fall well short of clinical doses. **Collagen** is listed at just 50 mg in an unhydrolyzed gelatin form — clinical studies use 2,500–10,000 mg of hydrolyzed peptides, so you're getting roughly 1% of a studied dose. **Biotin** at 5,000 mcg is the one ingredient at a meaningful level, though research supporting biotin for hair growth is largely limited to people with actual deficiency.

**Vitamin D3** at 1,000 IU hits the minimum clinical threshold, and the formula includes a basic spread of B vitamins — though all use budget forms like cyanocobalamin and folic acid rather than their bioactive counterparts. **Magnesium** is dosed at 50 mg in oxide form, which has roughly 4% absorption, giving you very little usable mineral. **Zinc** at 7.5 mg lands at half the minimum supplement range.

The biggest gap is the one that matters most for a hair, skin, and nails product: the collagen and supporting ingredients are dosed so far below clinical ranges that they won't meaningfully contribute to skin or hair outcomes. You're essentially getting a basic multivitamin with a high-dose biotin add-on.

BioStacks
21st Century

Extra Strength Hair, Skin & Nails

Tablet · 30 servings · $0.33/serving

41 / 100Average

Score Breakdown

Formulation
55
Safety
69
Final score
41/100

Ingredients (23)

Biotin5000 mcg

Optimal dose · Premium form

Vitamin D3Synergy1000 IU

Within effective range · Premium form

Niacin25 mg

Within effective range

Vitamin ASynergy1500 mcg

Optimal dose

Pantothenic Acid15 mg

30% of effective dose · Premium form

Label Nutrition Facts

Other Ingredients

Fillers, coatings, and additives

7Safe3Caution

TalcAnti-caking

Caution

MaltodextrinBinder

Caution

Polysorbate 80Emulsifier

Caution

Magnesium StearateLubricant

Safe

PEG/PVA CopolymerCoating

Safe

Polyvinyl AlcoholCoating

Safe

Silicon DioxideAnti-caking

Safe

Microcrystalline CelluloseBinder

Safe

Track this supplement in your stack

Get personalized insights, interactions, and coverage recommendations.

Get Started Free

Similar Supplements

Products that cover similar health dimensions based on their ingredients.

Sources & Scoring

Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).

This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.

The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.