Despite the name, this product's headline hair and skin ingredients fall well short of clinical doses. **Collagen** is listed at just 50 mg in an unhydrolyzed gelatin form — clinical studies use 2,500–10,000 mg of hydrolyzed peptides, so you're getting roughly 1% of a studied dose. **Biotin** at 5,000 mcg is the one ingredient at a meaningful level, though research supporting biotin for hair growth is largely limited to people with actual deficiency.
**Vitamin D3** at 1,000 IU hits the minimum clinical threshold, and the formula includes a basic spread of B vitamins — though all use budget forms like cyanocobalamin and folic acid rather than their bioactive counterparts. **Magnesium** is dosed at 50 mg in oxide form, which has roughly 4% absorption, giving you very little usable mineral. **Zinc** at 7.5 mg lands at half the minimum supplement range.
The biggest gap is the one that matters most for a hair, skin, and nails product: the collagen and supporting ingredients are dosed so far below clinical ranges that they won't meaningfully contribute to skin or hair outcomes. You're essentially getting a basic multivitamin with a high-dose biotin add-on.
21st Century
Extra Strength Hair, Skin & Nails
Tablet · 30 servings · $0.33/serving
Supports
Score Breakdown
Ingredients (23)
22 scored · 1 not scored
Optimal dose · Premium form
Within effective range · Premium form
Within effective range
Optimal dose
30% of effective dose · Premium form
Label Nutrition Facts
Active Ingredients
From the label · % Daily Value
Vitamin A1500 mcg
Vitamin C60 mg
Vitamin D325 mcg
Vitamin E6.75 mg
Thiamine5 mg
Other Ingredients
Fillers, coatings, and additives
TalcAnti-caking
Magnesium StearateLubricant
PEG/PVA CopolymerCoating
Polyvinyl AlcoholCoating
Silicon DioxideAnti-caking
Microcrystalline CelluloseBinder
Croscarmellose SodiumDisintegrant
MaltodextrinBinder
Track this supplement in your stack
Get personalized insights, interactions, and coverage recommendations.
Get Started FreeSimilar Supplements
Products that cover similar health dimensions based on their ingredients.
Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.