Despite the name, this product's headline hair and skin ingredients fall well short of clinical doses. **Collagen** is listed at just 50 mg in an unhydrolyzed gelatin form — clinical studies use 2,500–10,000 mg of hydrolyzed peptides, so you're getting roughly 1% of a studied dose. **Biotin** at 5,000 mcg is the one ingredient at a meaningful level, though research supporting biotin for hair growth is largely limited to people with actual deficiency.

**Vitamin D3** at 1,000 IU hits the minimum clinical threshold, and the formula includes a basic spread of B vitamins — though all use budget forms like cyanocobalamin and folic acid rather than their bioactive counterparts. **Magnesium** is dosed at 50 mg in oxide form, which has roughly 4% absorption, giving you very little usable mineral. **Zinc** at 7.5 mg lands at half the minimum supplement range.

The biggest gap is the one that matters most for a hair, skin, and nails product: the collagen and supporting ingredients are dosed so far below clinical ranges that they won't meaningfully contribute to skin or hair outcomes. You're essentially getting a basic multivitamin with a high-dose biotin add-on.

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BioStacks

21st Century

Extra Strength Hair, Skin & Nails

Tablet · 30 servings · $0.33/serving

48 / 100Average

Score Breakdown

Formulation
55
Safety
82
Final score
48/100

Ingredients (23)

22 scored · 1 not scored

Biotin5000 mcg

Optimal dose · Premium form

Vitamin D31000 IU

Within effective range · Premium form

Niacin25 mg

Within effective range

Vitamin A1500 mcg

Optimal dose

Pantothenic Acid15 mg

30% of effective dose · Premium form

Label Nutrition Facts

Active Ingredients

From the label · % Daily Value

DV%

Vitamin A1500 mcg

167%

Vitamin C60 mg

67%

Vitamin D325 mcg

167%

Vitamin E6.75 mg

45%

Thiamine5 mg

417%

Other Ingredients

Fillers, coatings, and additives

9Safe1Caution

TalcAnti-caking

Caution

Magnesium StearateLubricant

Safe

PEG/PVA CopolymerCoating

Safe

Polyvinyl AlcoholCoating

Safe

Silicon DioxideAnti-caking

Safe

Microcrystalline CelluloseBinder

Safe

Croscarmellose SodiumDisintegrant

Safe

MaltodextrinBinder

Safe

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Sources & Scoring

Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).

This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.

The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.