If you're looking for natural mood support, this formula targets serotonin production through two complementary pathways. **5-HTP** at 100 mg provides a direct precursor to serotonin — most clinical studies use 100–300 mg daily, so you're at the lower end of the effective range. **Saffron Extract** at 177 mg (standardized to safranal) is well above the 28–30 mg dose used in mood-focused RCTs, giving you a generous amount of a botanical with solid evidence for emotional wellbeing.
**Vitamin B6** at 20 mg (including the active P5P form), **Folate** at 400 mcg (as Quatrefolic methylfolate), and **B12** at 500 mcg (as methylcobalamin) round out the formula. What this means for you: these B vitamins are cofactors in neurotransmitter synthesis, and all three are dosed well and use premium bioavailable forms.
The important safety note: this product should not be combined with antidepressant or MAOI medications, as both 5-HTP and saffron can affect serotonin levels. Consult your doctor if you're on any mood-related medication.
BrainMD
Serotonin Mood Support, 120 Vegan Capsules
Capsule · 30 servings · $1.75/serving
Supports
Score Breakdown
Ingredients (5)
Within effective range · Premium form
Within effective range · Premium form
Optimal dose
Partial dose · Standard form
Within effective range
Label Nutrition Facts
Active Ingredients
From the label · % Daily Value
Vitamin B620 mg
Folate400 mcg DFE
Vitamin B12500 mcg
Saffron Extract177 mg
5-HTP100 mg
Other Ingredients
Fillers, coatings, and additives
Magnesium StearateLubricant
Silicon DioxideAnti-caking
Microcrystalline CelluloseBinder
Microcrystalline CelluloseBinder
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Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.