If you're looking for mood support, **St. John's Wort** is one of the most studied herbal options available — multiple meta-analyses show it can help with mild-to-moderate low mood, with effect sizes comparable to standard treatments in some trials. This product delivers 300mg standardized to 0.3% hypericin, which matches the exact dose and standardization used in the majority of clinical research.
The one-capsule-per-day dosing makes it straightforward. Some studies used 300mg three times daily (900mg total), so depending on your needs, you may want to discuss higher intake with a healthcare professional.
St. John's Wort has significant drug interactions — it can reduce the effectiveness of birth control, blood thinners, antidepressants (SSRIs/MAOIs), and other medications by accelerating their metabolism. This is clearly flagged in the product's own warnings, and you should take it seriously before starting.
BioStacks
Best for
Ingredients (1)
St. John's Wort Flowering Tops Extract
50%Dose
300 mg
Target
600–1200 mg
Form
Standard
Other Ingredients (5)
MaltodextrinBinder
Spikes blood sugar faster than table sugar (glycemic index 85–105). Research links it to gut bacteria changes that may promote intestinal inflammation (Nickerson et al. 2015). Used as a cheap filler — adds nothing beneficial.
Rice FlourFiller
Rice-based ingredients carry risk of inorganic arsenic contamination (FDA and Consumer Reports). Rice accumulates arsenic from soil at higher rates than other grains. Used as a cheap filler — adds nothing beneficial.
Silicon DioxideAnti-caking
Fine silica powder used to prevent clumping
Microcrystalline CelluloseBinder
Plant-derived cellulose used as a binder and filler in supplements
Stearic AcidLubricant
Saturated fatty acid used as tablet lubricant
How to Take It
Best taken in the morning
Take earlier in the day with food. Check the conflicts below — it interacts seriously with serotonergic compounds.
With food
On the label
Suggested use: Take 1 capsule daily, with or without food. Best when taken as directed by a qualified healthcare professional.
Do not combine with 5-HTP, SAMe or Tryptophan
Each of these raises serotonin activity on top of St. John's Wort, and together they can trigger serotonin syndrome — agitation, rapid heartbeat, raised blood pressure. Not without medical supervision.
General guidance based on the ingredients, not a substitute for the label or your doctor.
Price Check
$6.74
Cheaper than 94% of 24 st. john's wort supplements
Track this supplement in your stack
Get personalized insights, interactions, and coverage recommendations.
Get Started FreeSimilar Supplements
Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from the NIH Office of Dietary Supplements and the National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. studied ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.