KAL Betaine HCl+ targets stomach-acid and protein-digestion support, but at 328mg of **Betaine HCl** per tablet it lands below the doses digestive protocols typically use. The idea is to add hydrochloric acid to your stomach to help break down protein when your own acid is suspected to be low. Your label shows this as 250mg of betaine from 328mg of betaine hydrochloride, while the typical digestive range runs 650–2,500mg and the one study that actually measured its effect on stomach acid used 1,500mg — so a single tablet gives you roughly half the usual starting amount. Evidence is limited overall: no controlled trials have shown betaine HCl improves digestion or nutrient absorption.

The 130mg of **Pepsin** pairs with the acid as a protein-digesting enzyme and sits inside the typical 50–300mg formulation range. The catch is that pepsin's strength is properly measured in activity units, not milligrams, so the 130mg figure alone doesn't tell you how active it is — and no controlled human trials back supplemental pepsin for digestive outcomes. The 32mg of calcium comes from calcium carbonate in the tablet base, far below a dose that contributes to any health goal.

The label suggests one tablet with a meal, so reaching the 650mg+ that digestive protocols start from would mean two or more per meal. Worth knowing: betaine HCl can trigger heartburn or stomach irritation, especially if your stomach acid isn't genuinely low — this is a targeted tool for suspected low stomach acid, not a general digestive aid.

BioStacks
KAL

Betaine HCl+

1 Tablet · 100 servings · $0.12/serving

iHerbAmazon

Ingredients (3)

Pepsin

100%

Dose

130 mg

Target

50–300 mg

Form

—

Betaine HCl

50%

Dose

328 mg

Target

650–2500 mg

Form

Premium

Calcium

32 mg

Trace amount — not scored

Other Ingredients (3)

Silicon DioxideAnti-caking

Fine silica powder used to prevent clumping

Magnesium StearateLubricant

A salt of stearic acid used as a lubricant in tablet and capsule production

Microcrystalline CelluloseBinder

Plant-derived cellulose used as a binder and filler in supplements

How to Take It

Take it anytime

Timing doesn't matter for this one — taking it consistently does.

With or without food

On the label

Take 1 tablet with or immediately following a meal. Do not chew tablets. Use only as directed.

General guidance based on the ingredients, not a substitute for the label or your doctor.

Price Check

$12.29

$10$20$50

Cheaper than 93% of 14 betaine hydrochloride supplements

Track this supplement in your stack

Get personalized insights, interactions, and coverage recommendations.

Get Started Free

Similar Supplements

SpectraZyme Betaine HCI + Pepsin

Metagenics

SpectraZyme Betaine HCI + Pepsin

42
PDA Combination

Nature's Sunshine

PDA Combination

42
Vegan Betaine HCL & Pepsin

Solaray

Vegan Betaine HCL & Pepsin

41
Betaine Hydrochloride With Pepsin

Metabolic Maintenance

Betaine Hydrochloride With Pepsin

40
Betaine & Pepsin

Ortho Molecular Products

Betaine & Pepsin

40

Sources & Scoring

Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).

This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.

The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.

BioStacks

Know exactly what's in your supplements.

Navigate

  • Home
  • App Store
  • Google Play

Resources

  • Contact & Support
  • Pricing
  • Terms of Service
  • Privacy Policy
  • Refund Policy

Explore

  • Health Areas
  • Best Supplements
  • Nutrients
  • All Supplements

Popular Picks

  • Best Magnesium for Sleep
  • Best Collagen for Skin
  • Best Creatine for Muscle
  • Best Vitamin D for Bone Health
  • Best Probiotics for Digestion
  • Best CoQ10 for Heart

Free Tools

  • Interaction Checker
  • Dose Checker
  • Form Comparison

Field Guides

  • Magnesium for sleep
  • Reading labels
  • Interaction checker
  • Dose checker
  • Harmful ingredients
  • Proprietary blends
  • Stack building
  • Scan without barcode
  • All guides →
© 2026 BioStacks. All rights reserved. Not medical advice.