Designed to support your mood and sleep through serotonin production, this formula delivers 1,000mg of **L-Tryptophan** per three-capsule serving — right at the top of the clinical range used in research on sleep onset and emotional well-being. That's a full therapeutic dose, and the inclusion of 66mg **Niacin** (as niacinamide) helps ensure your body channels tryptophan toward serotonin rather than diverting it to make niacin on its own.

You're also getting 250mg of **L-Lysine** and a 285mg proprietary blend of hops and rosemary extracts. Lysine may help modulate serotonin receptors involved in stress-related anxiety, though 250mg is well below the 1,000mg+ doses studied for that purpose. The hops extract (Perluxan) has some preliminary evidence for calming support.

The main caveat is the three-capsule serving size — you need all three to reach the studied tryptophan dose. If you take fewer, you're getting a proportionally reduced benefit. Also worth noting: the precautions flag interactions with SSRIs and MAOIs, so check with your doctor if you're on mood-related medication.

BioStacks
Life Extension

Optimized Tryptophan Plus, 90 Vegetarian Capsules

Capsule · 30 servings · $0.80/serving

51 / 100Average

Supports

Score Breakdown

Formulation
59
Safety
87
Final score
51/100

Ingredients (4)

Niacin66 mg

Within effective range

L-Tryptophan1000 mg

Within effective range

Proprietary Tryptophan Plus Blend285 mg

Within effective range

L-Lysine250 mg

25% of effective dose

Label Nutrition Facts

Other Ingredients

Fillers, coatings, and additives

5Safe1Caution

MaltodextrinBinder

Caution

Silicon DioxideAnti-caking

Safe

Microcrystalline CelluloseBinder

Safe

Microcrystalline CelluloseBinder

Safe

StarchBinder

Safe

Microcrystalline CelluloseBinder

Safe

vegetable stearate

Unknown

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Sources & Scoring

Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).

This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.

The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.