Designed to support your mood and sleep through serotonin production, this formula delivers 1,000mg of **L-Tryptophan** per three-capsule serving — right at the top of the clinical range used in research on sleep onset and emotional well-being. That's a full therapeutic dose, and the inclusion of 66mg **Niacin** (as niacinamide) helps ensure your body channels tryptophan toward serotonin rather than diverting it to make niacin on its own.
You're also getting 250mg of **L-Lysine** and a 285mg proprietary blend of hops and rosemary extracts. Lysine may help modulate serotonin receptors involved in stress-related anxiety, though 250mg is well below the 1,000mg+ doses studied for that purpose. The hops extract (Perluxan) has some preliminary evidence for calming support.
The main caveat is the three-capsule serving size — you need all three to reach the studied tryptophan dose. If you take fewer, you're getting a proportionally reduced benefit. Also worth noting: the precautions flag interactions with SSRIs and MAOIs, so check with your doctor if you're on mood-related medication.
BioStacks
Life Extension
Optimized Tryptophan Plus, 90 Vegetarian Capsules
3 Capsules · 30 servings · $0.80/serving
Best for
Ingredients (4)
Niacin
100%Dose
66 mg
Target
25–500 mg
Form
Standard
L-Tryptophan
100%Dose
1000 mg
Target
250–1000 mg
Form
—
Proprietary Tryptophan Plus Blend
100%Dose
285 mg
Target
250–1000 mg
Form
—
L-Lysine
25%Dose
250 mg
Target
1000–3000 mg
Form
—
Other Ingredients (7)
MaltodextrinBinder
Spikes blood sugar faster than table sugar (glycemic index 85–105). Research links it to gut bacteria changes that may promote intestinal inflammation (Nickerson et al. 2015). Used as a cheap filler — adds nothing beneficial.
Silicon DioxideAnti-caking
Fine silica powder used to prevent clumping
Vegetable StearateLubricant
A plant-derived salt of stearic acid (typically magnesium or calcium) used as a tablet lubricant
Microcrystalline CelluloseBinder
Plant-derived cellulose used as a binder and filler in supplements
Microcrystalline CelluloseBinder
Plant-derived cellulose used as a binder and filler in supplements
StarchBinder
Carbohydrate polymer used as a binder, filler, and disintegrant in tablets and capsules
Microcrystalline CelluloseBinder
Plant-derived cellulose used as a binder and filler in supplements
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Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.