This product delivers 100 mg of **5-HTP** (5-Hydroxytryptophan) per chewable tablet, sourced from Griffonia simplicifolia seeds. 5-HTP is a direct precursor to serotonin, the neurotransmitter that regulates mood and converts into melatonin to support your sleep-wake cycle. At 100 mg, this sits at the entry point of the commonly studied range (100-300 mg), making it a reasonable starting dose.
The clinical evidence behind 5-HTP for stress and mood is limited. A few small trials suggest it may support serotonin levels, but there are no large-scale meta-analyses confirming its effectiveness for stress relief in otherwise healthy individuals. The mechanistic logic is strong — your body does use 5-HTP to make serotonin — but the human trial data has not caught up yet. If you respond well to the 100 mg dose, the research supports going up to 300 mg.
One important safety note: 5-HTP should not be combined with SSRIs, MAOIs, or triptan medications, as stacking serotonin-boosting compounds raises the risk of serotonin syndrome, a potentially serious condition. The chewable format and citrus flavoring make this easy to take — best on an empty stomach at bedtime as directed.
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What it does
5-Hydroxytryptophan
Form not confirmedGrade —
Studied for low mood, but reliable evidence of benefit remains insufficient.
Ingredients (1)
Other ingredients
XylitolSweetener
A FODMAP sugar alcohol that can cause GI distress (bloating, gas, diarrhea) at moderate doses (>10-20g/day), though supplement amounts are typically small. Extremely toxic to dogs — households with pets should store securely.
AnnattoColorant
Natural yellow-orange colorant derived from the seeds of the achiote tree (Bixa orellana)
Natural FlavorsFlavor
Broad regulatory category of flavor constituents derived from natural sources. Composition is proprietary and not disclosed — 'Natural Flavors' can include several hundred different compounds depending on the target flavor profile, including hexane-extracted constituents and proprietary carrier solvents. 'Natural' is a regulatory definition (21 CFR §101.22), not a safety guarantee.
Silicon DioxideAnti-caking
Fine silica powder used to prevent clumping
Citric AcidAcidulant
Natural acid derived from citrus fruits
Hydroxypropyl CelluloseBinder
An inert modified-cellulose polymer used as a binder, film-former, and disintegrant.
Microcrystalline CelluloseBinder
Plant-derived cellulose used as a binder and filler in supplements
Stearic AcidLubricant
Saturated fatty acid used as tablet lubricant
Lab testing
How to take it
On an empty stomach
Keep it away from protein-heavy meals
Space it a couple of hours from SAMe
On the label
Suggested Usage: Take 1 chewable tablet daily, preferably on an empty stomach at bedtime.
Do not combine with St. John's Wort
Each of these raises serotonin activity on top of St. John's Wort, and together they can trigger serotonin syndrome — agitation, rapid heartbeat, raised blood pressure. Not without medical supervision.
Price check
$17.13
Near the median of 61 5-HTP supplements
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Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from the NIH Office of Dietary Supplements and the National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. studied ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.
Not medical advice. Consult your healthcare professional.