If you're looking for methylation and performance support, this product hits the clinical sweet spot. A single three-tablet serving delivers 3,000mg of **Trimethylglycine (TMG)**, landing squarely in the 2,500–6,000mg range studied in research on homocysteine reduction and exercise performance.
At 3,000mg daily, you're at the dose shown to support power output and body composition in athletic performance trials — without crossing the 4,000mg threshold where some studies have observed elevated LDL cholesterol. The betaine anhydrous form is the standard used in clinical research.
The tradeoff is pill burden. You need three tablets per serving, and the label suggests up to three tablets twice daily (6,000mg). The product is also highly sensitive to moisture, so you'll need to keep the bottle sealed tightly between uses.
BioStacks
Other Ingredients (6)
Magnesium StearateLubricant
A salt of stearic acid used as a lubricant in tablet and capsule production
Coating (unspecified)Coating
Generic tablet coating declaration where the label does not itemize the coating's components; modern aqueous film coatings are typically cellulose-based (HPMC) with a plasticizer
Croscarmellose SodiumDisintegrant
Cross-linked cellulose derivative used as a superdisintegrant
Hydroxypropyl CelluloseBinder
An inert modified-cellulose polymer used as a binder, film-former, and disintegrant.
Microcrystalline CelluloseBinder
Plant-derived cellulose used as a binder and filler in supplements
Stearic AcidLubricant
Saturated fatty acid used as tablet lubricant
How to Take It
Take it anytime
Timing doesn't matter for this one — taking it consistently does.
With or without food
On the label
Take 1-3 tablets twice daily, preferably with food.
General guidance based on the ingredients, not a substitute for the label or your doctor.
Price Check
$17.14
Near the median of 21 TMG (Trimethylglycine) supplements
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Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from the NIH Office of Dietary Supplements and the National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. studied ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.