Best Artichoke for Digestion
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Last reviewed May 2026
Clinical dose: 300–640 mg
Why Artichoke for Digestion
Artichoke plays a supporting role in digestion. Artichoke leaf extract contains cynarin and chlorogenic acid, which stimulate bile production and support fat digestion. Multiple clinical trials and a Cochrane review support its use for functional dyspepsia (indigestion) and mild cholesterol reduction. In clinical studies, artichoke stimulates bile production for improved fat digestion and liver detox.
What dose to look for
Clinical studies typically use 300–640 mg of artichoke. Most clinical studies use 300–640 mg/day of standardized leaf extract. Higher doses (up to 1800 mg) used in dyspepsia and cholesterol studies. Typically standardized to cynarin and chlorogenic acid content. Products below this range may not deliver meaningful results.
What the research says
Artichoke has moderate clinical evidence for digestion benefits. Multiple clinical trials and a Cochrane review support its use for indigestion and mild cholesterol reduction Learn more
Clinical research on Artichoke Extract (Cynara scolymus)
LOW — Small RCTs for dyspepsia and IBS; choleretic mechanism · 320–640 mg/day (standardized to 2.5–5% cynarin)
- •2015 RCT (247 patients with functional dyspepsia) found artichoke leaf extract significantly reduced dyspepsia severity scores over 6 weeks compared to placebo. PubMed
- •2003 RCT (208 IBS patients) found artichoke extract reduced IBS symptom incidence from 26% to 13% over 2 months — but the trial was unblinded, limiting reliability. PubMed
- •Mechanism: cynarin and chlorogenic acid stimulate bile production (choleretic effect), which aids fat digestion. May explain benefit for post-prandial bloating and heaviness. Also has hepatoprotective properties.