Best Magnolia & Phellodendron Blend for Stress & Mood
Top 1 products ranked
Last reviewed May 2026
Clinical dose: 250–750 mg
Why Magnolia & Phellodendron Blend for Stress & Mood
Magnolia & Phellodendron Blend plays a supporting role in stress & mood. Proprietary blend of Magnolia officinalis and Phellodendron amurense bark extracts, standardized to honokiol and berberine. Two small manufacturer-funded RCTs showed mixed cortisol results but consistent self-reported stress/anxiety reduction.
What dose to look for
Clinical studies typically use 250–750 mg of magnolia & phellodendron blend. RCTs used 500–750 mg/day. Standard dose is 250 mg 2–3x/day. Products below this range may not deliver meaningful results.
What the research says
Magnolia & Phellodendron Blend has limited clinical evidence for stress & mood benefits. Only 2 small manufacturer-funded clinical trials; consistent self-reported stress reduction but limited data Learn more
Clinical research on Relora (Magnolia + Phellodendron)
LOW — 2 small manufacturer-funded RCTs, conflicting cortisol · 250 mg 2–3x/day (500–750 mg/day total)
- •Talbott 2013 (63 adults, 42 days, 750 mg/day): reduced salivary cortisol by 18% (p<0.05) and improved POMS vigor and fatigue subscales. Manufacturer-funded.
- •Kalman 2008 (56 adults, 4 weeks, 500 mg/day): NO significant cortisol reduction. Reduced weight gain associated with stress eating. Manufacturer-funded.
- •Conflicting cortisol results across the two available RCTs — one positive, one null. Both had small samples and industry funding.
- •Mechanism: honokiol (magnolia) is a GABAergic anxiolytic; berberine (phellodendron) modulates cortisol. GABAergic mechanism is well-characterized but clinical translation is limited.
