Best Reishi mushroom for Immune
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Last reviewed May 2026
Clinical dose: 1000–3000 mg
Why Reishi mushroom for Immune
Reishi mushroom plays a supporting role in immune. Reishi is a medicinal mushroom traditionally used for immune support and as an adaptogen. No established RDA/UL. In clinical studies, reishi mushroom traditionally used for immune support.
What dose to look for
Clinical studies typically use 1000–3000 mg of reishi mushroom. Reishi mushroom extract range for immune and adaptogenic support. Products below this range may not deliver meaningful results.
What the research says
Reishi mushroom has limited clinical evidence for immune benefits. Limited clinical trials in humans; most evidence comes from traditional use and preclinical studies Learn more
Clinical research on Reishi Mushroom (Ganoderma lucidum)
LOW — Long traditional use; limited and low-quality human RCTs · 1,000–3,000 mg/day (extract standardized to polysaccharides and triterpenes)
- •2015 Cochrane review of 5 RCTs (373 cancer patients) found reishi enhanced host immune responses (increased CD3+, CD4+, CD8+ T-cells) as an adjunct to conventional treatment, but study quality was very low. PubMed
- •In vitro studies show beta-glucans and triterpenes from reishi modulate dendritic cell maturation, macrophage activation, and NK cell cytotoxicity. Translation to clinical immune outcomes is unproven.
- •Several reports of hepatotoxicity from reishi extract — including one associated with powdered reishi in a cancer patient. Long-term safety profile is inadequately characterized.