Best TMG (Trimethylglycine) for Muscle
Top 1 products ranked
Last reviewed May 2026
Clinical dose: 2500–6000 mg
Why TMG (Trimethylglycine) for Muscle
TMG (Trimethylglycine) plays a supporting role in muscle. Betaine (TMG) is the methyl derivative of glycine, originally found in sugar beets. Primary mechanism: donates a methyl group to convert homocysteine → methionine via BHMT enzyme, also increasing SAMe production.
What dose to look for
Clinical studies typically use 2500–6000 mg of tmg (trimethylglycine). Performance: 2.5–3 g/day (below lipid-raising threshold). Homocysteine lowering: 4–6 g/day (but raises LDL/TC at ≥4 g/day). Average dietary intake is only ~182 mg/day. Products below this range may not deliver meaningful results.
What the research says
TMG (Trimethylglycine) has moderate clinical evidence for muscle benefits. Meta-analyses confirm it lowers homocysteine; modest strength gains at 2.5-3g/day in trials Learn more
