BioStacksBest TMG (Trimethylglycine) for Muscle
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Clinical dose: 2500–6000 mg
Why TMG (Trimethylglycine) for Muscle
When it comes to muscle, TMG (Trimethylglycine) is one of the most supporting nutrients to consider. Betaine (TMG) is the methyl derivative of glycine, originally found in sugar beets. Primary mechanism: donates a methyl group to convert homocysteine → methionine via BHMT enzyme, also increasing SAMe production. ⚠️ NOT the same as Betaine HCl, which is a digestive acid supplement — completely different product.
What dose to look for
Clinical studies typically use 2500–6000 mg of tmg (trimethylglycine). Performance: 2.5–3 g/day (below lipid-raising threshold). Homocysteine lowering: 4–6 g/day (but raises LDL/TC at ≥4 g/day). Average dietary intake is only ~182 mg/day. Supplements that fall short of this threshold are unlikely to match what clinical trials achieved.
The evidence behind tmg (trimethylglycine)
Research supporting tmg (trimethylglycine) for muscle is rated as moderate. Meta-analyses confirm it lowers homocysteine; modest strength gains at 2.5-3g/day in trials Learn more
