Best for General Health
Best Vitamin B2 for General Health
Top 30 products ranked · Reviewed May 2026 · 25–100 mg clinical dose
Why Vitamin B2 for General Health
Vitamin B2 plays a supporting role in general health. Precursor to the coenzymes FMN and FAD, which drive cellular energy production and antioxidant defense systems. Supports mitochondrial function and metabolism of carbohydrates and fats.
What dose to look for
Clinical studies typically use 25–100 mg of vitamin b2. B-complex supplements typically provide 25–100 mg. Products below this range may not deliver meaningful results.
What the research says
Vitamin B2 has strong clinical evidence for general health benefits. Precursor to FMN/FAD coenzymes for cellular energy; studied for migraine prevention at high doses Learn more
Clinical research on Riboflavin (Vitamin B2)
LOW for general supplementation; deficiency uncommon on a varied Western diet (migraine is a separate use case) · 1.1–1.3 mg/day (RDA); 400 mg/day for migraine prophylaxis
- •Schoenen RCT (55 adults): 400 mg/day for 3 months reduced migraine frequency with an NNT of 2.3 — striking, but a single small trial with limited, inconsistent replication. PubMed
- •No controlled trial shows riboflavin improves energy or fatigue in non-deficient adults — the B-complex 'energy boost' framing is mechanism repurposed as marketing.
- •Repletion reliably resolves the cracked-lip, sore-tongue, inflamed-eye signs of frank deficiency — the only context with strong, settled evidence; deficiency is uncommon in adults eating dairy or fortified foods.