About Bromelain
Bromelain is a proteolytic enzyme from pineapple stem used for digestive support and anti-inflammatory effects. RCTs support use for osteoarthritis (Walker 2002 at 200 mg/day showed knee OA benefit; Klein 2006 found 400 mg/day equivalent to diclofenac 100 mg), post-surgical inflammation, and sinusitis. Brien 2004 systematic review of OA trials (PMC538506) covers the 540–1,890 mg/day range. Activity is measured in GDU (Gelatin Digesting Units) in the US, FIP (Fédération Internationale Pharmaceutique) in Europe — 2,400 GDU/g ≈ 4.8 FIP/mg. mg dose alone is meaningless without potency. No established RDA/UL.
What Bromelain supports
- Supports protein digestion
- May reduce inflammation in osteoarthritis and post-surgical recovery
How much Bromelain to take
Clinical studies typically use 500–2400 gdu of Bromelain. 500–2,400 GDU/day. Anchored to: Walker 2002 OA RCT (200 mg/day ≈ 480 GDU @ 2,400 GDU/g, measurable benefit); Brien 2004 OA review (RCT range 540–1,890 mg/day); German Commission E (200–800 FIP × 2–3x daily ≈ 400–2,400 FIP/day). Modal commercial product (NOW/Doctor's Best/Pure 500 mg @ 2,400 GDU/g = 1,200 GDU) lands in therapeutic band. Conversions: 1 GDU ≈ 1.5 MCU; 2,400 GDU/g ≈ 4.8 FIP/mg.
- Effective range
- 500–2400 gdu
Clinical evidence
Moderate clinical evidence. Multiple clinical trials for osteoarthritis, post-surgical pain, and sinusitis support its use