About EPA
EPA is the primary anti-inflammatory omega-3 fatty acid. EPA-dominant formulas (≥60% EPA) outperform DHA-dominant formulas for mood and depression in multiple meta-analyses. The REDUCE-IT trial used 4g icosapent ethyl (pure EPA) and showed 25% cardiovascular event reduction. rTG form is ~70% better absorbed than ethyl ester. Premium suppliers: AlaskOmega, EPAX.
What EPA supports
- Reduces triglycerides and cardiovascular risk
- Supports mood and reduces depression symptoms
- Potent anti-inflammatory action
How much EPA to take
The RDA prevents deficiency. The effective range is what clinical trials used to actually move the outcome.
Effective
500–2000
mg
500mg minimum for general benefit; 1000-2000mg for mood/cardiovascular outcomes.
Clinical evidence
Strong clinical evidence. REDUCE-IT (n=8,179) showed 25% CV event reduction with pure EPA. Meta-analyses of 26 RCTs confirm EPA-dominant formulas superior for depression.
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