About Epitalon
A synthetic tetrapeptide (Ala-Glu-Asp-Gly) studied by Russian gerontologist Vladimir Khavinson for telomerase activation and anti-aging. One small, non-blinded Russian study reported increased telomere length in elderly subjects via injection — this study has never been replicated by independent researchers. In-vitro data shows telomerase activation in cell cultures. Zero human RCTs for oral supplementation exist. As a tetrapeptide, oral bioavailability is uncharacterized and likely very low. Popular in longevity/biohacking communities.
What Epitalon supports
- One unreplicated Russian injection study — zero oral human RCTs
- Telomerase activation claims are in vitro only; oral bioavailability unknown
How much Epitalon to take
Clinical studies typically use 1–10 mg of Epitalon. Supplement doses range 1–10 mg/day. One small Russian study (Khavinson, injection). No human RCTs for oral use. Oral bioavailability is uncharacterized.
- Effective range
- 1–10 mg
Clinical evidence
Limited clinical evidence. One small, non-blinded, unreplicated Russian injection study. Zero human RCTs for oral use. Telomerase claims are in vitro only.
NIH Fact Sheet