About Epitalon
A synthetic tetrapeptide (Ala-Glu-Asp-Gly) studied by Russian gerontologist Vladimir Khavinson for telomerase activation and anti-aging. One small, non-blinded Russian study reported increased telomere length in elderly subjects via injection — this study has never been replicated by independent researchers. In-vitro data shows telomerase activation in cell cultures. Zero human RCTs for oral supplementation exist. As a tetrapeptide, oral bioavailability is uncharacterized and likely very low. Popular in longevity/biohacking communities.
What Epitalon supports
- One unreplicated Russian injection study — zero oral human RCTs
- Telomerase activation claims are in vitro only; oral bioavailability unknown
How much Epitalon to take
The RDA prevents deficiency. The effective range is what clinical trials used to actually move the outcome.
Effective
1–10
mg
Supplement doses range 1–10 mg/day. One small Russian study (Khavinson, injection). No human RCTs for oral use. Oral bioavailability is uncharacterized.
Clinical evidence
Limited clinical evidence. One small, non-blinded, unreplicated Russian injection study. Zero human RCTs for oral use. Telomerase claims are in vitro only.
NIH Fact Sheet