About Iron
Essential for oxygen transport via hemoglobin and energy production in mitochondria. Iron bisglycinate (Ferrochel) offers 2–4x higher bioavailability than ferrous sulfate with significantly less GI distress—it's the preferred supplemental form. Vitamin C taken alongside iron substantially boosts absorption. Premenopausal women need 18 mg/day versus 8 mg for men. Unsupervised supplementation in non-deficient individuals can cause iron overload, so testing ferritin levels before supplementing is strongly recommended.
What Iron supports
- Transports oxygen in blood
- Fuels energy production
- Supports cognitive function
How much Iron to take
Clinical studies typically use 15–45 mg of Iron. 15-25 mg for prevention/maintenance, 25-45 mg for deficiency treatment. RDA is 8 mg (men) / 18 mg (premenopausal women). Bisglycinate forms effective at lower doses due to 2-4× bioavailability.
- RDA
- 8 mg
- Upper limit (UL)
- 45 mg
- Effective range
- 15–45 mg
Forms of Iron compared
- Iron bisglycinate (Ferrochel)Premium2–4× absorption of sulfate. Minimal GI distress.
- Heme ironPremiumAnimal-derived; highest bioavailability of any iron form.
- Ferrous ascorbateStandardIron + vitamin C in one molecule; ascorbate boosts non-heme absorption.
- Sucrosomial ironStandardPhospholipid-encapsulated iron; bypasses gut absorption blocks with minimal GI effects.
- Ferrous fumarateBudgetSignificant GI side effects
- Ferrous sulfateBudgetCommon GI side effects
- Ferrous gluconateBudgetLow elemental iron (12%)
- Carbonyl ironBudgetQuestionable absorption
- Polysaccharide ironBudgetPoor efficacy in trials
- Iron oxideBudgetMinimal absorption
Clinical evidence
Strong clinical evidence. Essential for oxygen transport via hemoglobin; bisglycinate form has 2-4x better absorption than ferrous sulfate
NIH Fact Sheet