LGG
Dosing Guide
RDA
None
Effective
5–40 B CFU
Upper Limit
None
Clinical range 5-40 billion CFU/day. Pediatric acute gastroenteritis benefit requires ≥10 billion CFU/day (Szajewska 2019 meta-analysis). AAD prevention: 5-40 billion CFU/day (Goldenberg Cochrane 2019). Dose is measured in CFU, not mg.
About LGG
Lactobacillus rhamnosus GG (LGG) is among the most-studied probiotic strains in humans. Isolated in 1983 at Tufts by Gorbach and Goldin (patent filed 1985, hence 'GG'). Reclassified in 2020 as Lacticaseibacillus rhamnosus. Strongest clinical evidence for pediatric antibiotic-associated diarrhea prevention. Acute gastroenteritis benefit shown in European cohorts but null in the 2018 Schnadower NEJM trial in US children. Marketed primarily as Culturelle. Survives gastric acid and adheres to intestinal mucosa. No established RDA/UL.