NAD+ Precursor (NR)

About NAD+ Precursor (NR)

NR is a form of vitamin B3 and a precursor to NAD+, a coenzyme essential for energy metabolism, DNA repair, and sirtuin activation. NAD+ levels decline ~42% between ages 30–70. NR dose-dependently raises blood NAD+ (22–142% at 100–1000 mg/day). Unlike niacin, NR does not cause flushing. Unlike high-dose niacinamide, NR does not inhibit sirtuins. NIAGEN is the patented, FDA GRAS form used in virtually all published human trials. Strong bioavailability evidence; clinical health outcomes still emerging. No established RDA/UL.

What NAD+ Precursor (NR) supports

• 🧬Dose-dependently raises NAD+ levels critical for cellular repair
• ⚡Supports mitochondrial function and energy metabolism
• ❤️Preliminary evidence for cardiovascular and vascular support
• ⏳Activates sirtuins and PARP enzymes linked to healthy aging

How much NAD+ Precursor (NR) to take

Clinical studies typically use 250–1000 mg of NAD+ Precursor (NR). Most human studies use 250–1000 mg/day. 300 mg is the most common consumer dose. Clinical trials typically use 1000 mg/day (500 mg twice daily).

Effective range

250–1000 mg

Forms of NAD+ Precursor (NR) compared

• NiagenPremium
  ChromaDex's branded NR chloride — the form behind nearly every published NR human trial.
• Nicotinamide riboside chloridePremium
  Stable salt form; same molecule as Niagen, often without 3rd-party testing.
• NR chloridePremium
  Generic NR chloride; verify identity testing on the COA.
• Nicotinamide riboside (generic)Standard
  Unspecified salt — stability and identity vary by manufacturer.

Clinical evidence

Moderate clinical evidence. Several human trials confirm it raises NAD+ levels dose-dependently, but health outcomes still emerging