About Resveratrol
Resveratrol is a polyphenol stilbene found in grape skin, red wine, and Japanese knotweed. Trans-resveratrol is the bioactive isomer. A 2019 meta-analysis (24 RCTs) found significant improvements in fasting glucose and insulin in type 2 diabetes patients. A 2015 meta-analysis (10 RCTs) showed significant systolic BP reduction at doses ≥150 mg/day. Activates SIRT1 and AMPK pathways relevant to cellular aging. However, bioavailability is very low (<1% unchanged in plasma), limiting translation from in vitro to clinical effects. Evidence for longevity claims in humans remains preliminary.
What Resveratrol supports
- May support cardiovascular health and blood pressure
- May improve insulin sensitivity in diabetic patients
- Activates SIRT1 pathway linked to cellular longevity
How much Resveratrol to take
Clinical studies typically use 150–500 mg of Resveratrol. Most RCTs use 150–500 mg/day of trans-resveratrol. Some cardiovascular studies use up to 1000 mg/day.
- Effective range
- 150–500 mg
Clinical evidence
Moderate clinical evidence. Meta-analyses show benefits for blood sugar and blood pressure, but bioavailability is very low (<1%)
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