About King of Bitters
Andrographis paniculata has moderate clinical evidence for reducing severity and duration of upper respiratory tract infections. A 2017 meta-analysis (33 RCTs, 7,175 patients) found significant improvements in cough and sore throat vs. placebo. Most effective when taken within 36–48 hours of symptom onset. Key active compound is andrographolide, which has poor oral bioavailability — standardized extracts strongly preferred over crude powder. Not recommended for continuous use >12 weeks. Contraindicated in pregnancy.
What King of Bitters supports
- Reduces severity and duration of cold symptoms (meta-analysis of 33 RCTs)
- Supports immune function by increasing T cell activity
How much King of Bitters to take
The RDA prevents deficiency. The effective range is what clinical trials used to actually move the outcome.
Effective
200–600
mg
Standardized extract range from RCTs. KalmCold (AP-Bio) clinically tested at 200–400 mg/day. Crude herb powder requires 3,000–6,000 mg/day.
Clinical evidence
Moderate clinical evidence. Meta-analysis of 33 trials (7,175 patients) found significant improvement in cold symptoms
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