About Apigenin
Apigenin is a flavonoid found in chamomile that acts as a mild GABA-A receptor ligand. Clinical evidence is almost entirely for chamomile extract, not isolated apigenin. Popularized by Andrew Huberman but no RCTs exist for isolated apigenin at 50 mg for sleep. Also inhibits CD38, raising NAD+ levels. No established RDA/UL.
What Apigenin supports
- May support sleep quality through mild sedative effects
- Mild anxiolytic effects via GABA-A modulation
How much Apigenin to take
The RDA prevents deficiency. The effective range is what clinical trials used to actually move the outcome.
Effective
50–200
mg
50 mg isolated apigenin is the popular protocol; clinical evidence is primarily for chamomile extract (500-1500 mg, which delivers ~5-15 mg apigenin).
Clinical evidence
Limited clinical evidence. No clinical trials for isolated apigenin at supplement doses; evidence is for chamomile extract only
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