About Bacillus subtilis
A spore-forming (soil-based) probiotic. The DE111 strain has RCTs showing survival/germination in the small intestine and immunomodulatory and GI effects in healthy adults. Note: this is distinct from Bacillus subtilis natto used to produce nattokinase (separate entry). Strain-specific evidence.
What Bacillus subtilis supports
- Spore form survives stomach acid and germinates in the gut
- DE111 has moderate RCT evidence for GI and immune support
How much Bacillus subtilis to take
The RDA prevents deficiency. The effective range is what clinical trials used to actually move the outcome.
Effective
1–5
billion_cfu
DE111 RCTs use ~1-5 billion CFU/day; spore-forming so dose is lower than typical lactic-acid probiotics. Often presence-only in blends; nominal range.
Clinical evidence
Moderate clinical evidence. Moderate: DE111 has human RCTs for GI/immune outcomes.
NIH Fact Sheet