About Fadogia Agrestis
Fadogia Agrestis is a Nigerian shrub traditionally used as an aphrodisiac. Animal studies in rats show dose-dependent increases in testosterone and sexual behavior, but also testicular toxicity at higher doses (100 mg/kg). There are no standalone human RCTs — a 2023 pilot study tested Fadogia combined with Tongkat Ali but cannot isolate Fadogia's individual contribution. Popularized by Andrew Huberman's podcast but clinical evidence in humans does not yet support the claims. Safety profile in humans is poorly characterized; the animal toxicity findings warrant caution.
What Fadogia Agrestis supports
- May support testosterone levels (animal data only)
- No human RCTs — evidence is preliminary
How much Fadogia Agrestis to take
The RDA prevents deficiency. The effective range is what clinical trials used to actually move the outcome.
Effective
400–600
mg
No human RCTs establish an optimal dose. 400–600 mg/day is the supplement market consensus, extrapolated from rat studies. Animal studies used 18–100 mg/kg body weight.
Clinical evidence
Limited clinical evidence. No human clinical trials exist; only rat studies showing testosterone effects and testicular toxicity
Examine.com