About Grape Seed Extract
Grape seed extract is rich in oligomeric proanthocyanidins (OPCs). Meta-analysis of 16 RCTs found significant blood pressure reduction (SBP -6.08, DBP -2.80 mmHg), especially in younger (<50), obese, and metabolic syndrome patients. A 50-trial meta-analysis found significant reductions in fasting glucose, total cholesterol, LDL, and triglycerides. Meta-analysis of 19 trials showed reduced oxidative stress markers (MDA) and hs-CRP. However, a smaller 9-trial meta-analysis found only modest BP effects and no lipid changes. Effect sizes are moderate and population-dependent. Products standardized to ≥95% OPCs reflect what was used in trials.
What Grape Seed Extract supports
- May reduce blood pressure by ~6 mmHg systolic
- Reduces oxidative stress markers
How much Grape Seed Extract to take
Clinical studies typically use 150–600 mg of Grape Seed Extract. Most RCTs use 150–300 mg/day. Typically standardized to ≥95% oligomeric proanthocyanidins (OPCs).
- Effective range
- 150–600 mg
Clinical evidence
Moderate clinical evidence. Meta-analyses of 16-50 trials show significant blood pressure and cholesterol improvements
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