About Nicotinamide adenine dinucleotide
The central redox coenzyme, sold directly as NAD+ or NADH (distinct from precursors like NMN or NR). Oral absorption of the intact molecule is doubtful, and human evidence is limited to small studies in fatigue and Parkinson's. Precursor forms are generally better studied.
What Nicotinamide adenine dinucleotide supports
- Central energy coenzyme; oral absorption and clinical benefit are uncertain
How much Nicotinamide adenine dinucleotide to take
The RDA prevents deficiency. The effective range is what clinical trials used to actually move the outcome.
Effective
5–50
mg
Oral NADH studies (fatigue, Parkinson's) have used roughly 5-50 mg/day; oral bioavailability of intact NAD+/NADH is questionable. Range is nominal.
Clinical evidence
Limited clinical evidence. Small studies only; oral bioavailability of intact NAD questionable.