About Nattokinase
Nattokinase is a fibrinolytic enzyme from fermented soybeans (natto). A 2023 meta-analysis of 6 RCTs found significant reductions in systolic BP (-3.45 mmHg) and diastolic BP (-2.32 mmHg). Single-dose studies confirm enhanced fibrinolytic activity via elevated D-dimer. May have anticoagulant effects — caution with blood thinners.
What Nattokinase supports
- May reduce blood pressure based on meta-analysis of 6 RCTs
- Enhances fibrinolytic activity — supports healthy blood clot breakdown
How much Nattokinase to take
Clinical studies typically use 2000–4000 fu of Nattokinase. 2,000-4,000 FU/day for cardiovascular support. Meta-analysis of 6 RCTs (546 subjects) showed significant BP reduction at 2,000 FU. Higher doses (10,800 FU) may be needed for lipid effects.
- Effective range
- 2000–4000 fu
Clinical evidence
Moderate clinical evidence. Meta-analysis of 6 trials (546 subjects) showed significant blood pressure reduction
NIH Fact Sheet