About Palmitoleic Acid (Omega-7)
Palmitoleic acid (16:1 n-7) is a monounsaturated omega-7 fatty acid; Provinal is a purified (macadamia/fish-derived) branded form. A few small short RCTs suggest reductions in CRP, triglycerides and LDL and a modest HDL rise at ~210 mg/day, and a 12-week RCT reported skin-barrier improvement. However the evidence base is thin, short, sometimes industry-linked, and mixed (a mixed omega-7 supplement at ~688 mg/day showed no anti-inflammatory effect, and one lipid RCT was formally withdrawn). Grades low pending larger independent replication.
What Palmitoleic Acid (Omega-7) supports
- Small short-term trials suggest modest improvements in triglycerides and LDL, though results are inconsistent and unreplicated at scale
- One 12-week RCT reported improved skin barrier hydration, from a single study
How much Palmitoleic Acid (Omega-7) to take
The RDA prevents deficiency. The effective range is what clinical trials used to actually move the outcome.
Effective
210–500
mg
Small trials used ~210 mg/day palmitoleic acid (as 420 mg Provinal) up to 500 mg/day for 12 weeks. Doses are study-derived, not an established therapeutic standard.
Clinical evidence
Limited clinical evidence. A few small, short, partly industry-linked RCTs; mixed results and one withdrawn paper.
NIH Fact Sheet