BioStacks

Supplement

Phlorizin

Evidence

Limited
Evidence: 2 of 5 (Limited)

What the evidence says

Phloridzin is a dihydrochalcone polyphenol from apple tree bark and skin. It is a classic experimental SGLT inhibitor but is poorly absorbed orally (rapidly hydrolyzed to phloretin). No clinical efficacy evidence as a supplement.

Preclinical only; poor oral bioavailability, no human trials.

Top Phlorizin supplements

About Phlorizin

Phloridzin is a dihydrochalcone polyphenol from apple tree bark and skin. It is a classic experimental SGLT inhibitor but is poorly absorbed orally (rapidly hydrolyzed to phloretin). No clinical efficacy evidence as a supplement.

What Phlorizin supports

  • Apple-derived polyphenol studied for glucose handling in the lab - no human supplement evidence

Clinical evidence

Limited clinical evidence. Preclinical only; poor oral bioavailability, no human trials.

NIH Fact Sheet