About Serrapeptase
Proteolytic enzyme from Serratia marcescens. 1 systematic review (24 studies), 1 meta-analysis (5 RCTs), and ~11-20 total RCTs — mostly for post-surgical swelling and sinusitis. Positive results for edema reduction post-surgery, though most trials are small (n<200) and older. The 2013 systematic review noted quality concerns but acknowledged efficacy signals. Mechanism well-understood (serine protease with fibrinolytic and anti-inflammatory properties).
What Serrapeptase supports
- Some evidence for reducing post-surgical swelling and edema
- May reduce mucus viscosity in chronic airway conditions
How much Serrapeptase to take
Clinical studies typically use 40000–120000 spu of Serrapeptase. RCTs typically use 10mg 3x/day (≈60,000 SPU/day). Range covers single-dose products (40,000-120,000 SPU) matching total daily RCT doses. 1mg ≈ 2,000 SPU.
- Effective range
- 40000–120000 spu
Clinical evidence
Moderate clinical evidence. Systematic review of 24 studies for post-surgical swelling, mostly small and older studies
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