About Sulbutiamine
Synthetic derivative of thiamine (vitamin B1) that crosses the blood-brain barrier more readily. Small RCTs (mostly older, some industry-funded) suggest possible benefit for asthenia/fatigue; nootropic/memory claims are not well supported by quality human trials.
What Sulbutiamine supports
- May reduce fatigue/asthenia — based on small older RCTs; cognitive-enhancement claims are not well supported
How much Sulbutiamine to take
The RDA prevents deficiency. The effective range is what clinical trials used to actually move the outcome.
Effective
400–600
mg
Doses used in small RCTs for fatigue/asthenia; not an established therapeutic range for cognitive claims.
Clinical evidence
Limited clinical evidence. Limited, mostly older or industry-linked trials; no modern high-quality RCTs or meta-analyses.
NIH Fact Sheet