About Tauroursodeoxycholic Acid
TUDCA is a bile acid with RCT evidence in specific diagnosed conditions: UDCA/TUDCA is an approved prescription therapy for cholestatic liver disease and gallstones in some countries, and phase II trials combining TUDCA with riluzole showed slowed functional decline and a possible survival benefit in ALS. This condition-specific evidence should not be conflated with general 'liver detox' or wellness marketing claims at lower commercial doses, which lack dedicated RCT support.
What Tauroursodeoxycholic Acid supports
- Clinically studied for liver disease and ALS at higher, medically supervised doses — general wellness claims at lower supplement doses aren't directly supported by this research
How much Tauroursodeoxycholic Acid to take
The RDA prevents deficiency. The effective range is what clinical trials used to actually move the outcome.
Effective
250–500
mg
250-500 mg/day is the typical commercial supplement dose. Clinical trials for specific diagnosed conditions (e.g., ALS, primary biliary cirrhosis) used much higher, medically supervised doses (1,000-2,000+ mg/day) not appropriate to extrapolate to general wellness use.
Clinical evidence
Moderate clinical evidence. Real RCT evidence exists but is condition-specific (liver disease, ALS) and dosed higher than typical commercial supplements; general wellness use is extrapolated, not directly tested.
Reference