About Zinc
Involved in over 300 enzymes and critical for immune function, wound healing, protein synthesis, and DNA repair. Zinc picolinate and zinc bisglycinate are the best-absorbed supplemental forms, while zinc oxide has poor bioavailability. Long-term zinc supplementation above 40 mg/day can deplete copper stores—pairing with 1–2 mg copper is recommended at higher doses. Zinc lozenges (acetate or gluconate) may reduce cold duration when started within 24 hours of symptom onset.
What Zinc supports
- Strengthens immune defense
- Promotes skin healing
- Supports wound repair
How much Zinc to take
Clinical studies typically use 15–30 mg of Zinc. Common supplement dose; UL is 40 mg/day.
- RDA
- 11 mg
- Upper limit (UL)
- 40 mg
- Effective range
- 15–30 mg
Forms of Zinc compared
- Zinc picolinatePremiumHighest absorption of common zinc forms in head-to-head trials.
- Zinc bisglycinatePremiumChelated; gentle on the stomach with excellent uptake.
- Zinc monomethionine (OptiZinc)StandardPatented amino-acid bound form (OptiZinc).
- Zinc citrateStandardReasonable absorption at clinical doses.
- Zinc gluconateStandardCommon in lozenges; modest absorption.
- Zinc acetateStandardUsed in cold lozenges; effective topically in the throat.
- Zinc sulfateBudgetLower absorption, may cause nausea
- Zinc oxideBudgetPoorly absorbed
Clinical evidence
Strong clinical evidence. Meta-analyses of 30+ trials confirm immune benefits; reduces common cold duration by ~33%
NIH Fact Sheet