**Nattokinase** at 4,000 FU per capsule — right at the top of the clinically studied range for cardiovascular support. A meta-analysis of six RCTs found this dose range can modestly reduce blood pressure and enhance your body's natural ability to break down fibrin, the protein involved in blood clot formation. The NSK-SD branded form used here is vitamin K-free, which matters if you're on blood thinners.
The formula also includes a blend of digestive enzymes alongside the nattokinase, though the **Bromelain** at 96 GDU is well below the 1,200+ GDU range studied for anti-inflammatory benefits — at this dose, it's contributing to digestion rather than joint or inflammation support.
The directions suggest taking this on an empty stomach, which is important — nattokinase's fibrinolytic activity is best studied when taken away from food. If you're using blood-thinning medication, check with your doctor before adding this to your routine.
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What it does
A combination of 9 label ingredients.
Nattokinase
Mixed formsGrade —
Studied for blood pressure and clotting markers; heart-attack or stroke prevention is unestablished, and bleeding-related interactions need caution.
Calcium
calcium citratePremium
Supports the maintenance of normal bones and teeth, muscle function and nerve signaling.
Ingredients (9)
Other ingredients
Capsule ShellCapsule
Generic capsule shell where the label does not specify the material. Common materials are hypromellose (HPMC) for vegetarian capsules and gelatin for traditional capsules — both are GRAS-listed and safe. Fish gelatin and pullulan variants also exist.
Lab testing
How to take it
With or without food
On the label
Recommended Usage: Take 1 per day on an empty stomach (1/2 hour before or 2 hours after a meal). More may be taken as recommended by your healthcare practitioner.*
Price check
$46.99
Pricier than 88% of 10 nattokinase supplements
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Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from the NIH Office of Dietary Supplements and the National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. studied ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.
Not medical advice. Consult your healthcare professional.