About AKG
TCA-cycle keto-acid (distinct from arginine alpha-ketoglutarate/AAKG). Calcium-AKG is promoted for longevity/'biological age'. Human evidence is limited to small, largely industry-linked studies; most support is preclinical (mouse lifespan/healthspan). Generally well tolerated.
What AKG supports
- May support healthy aging and bone markers — human evidence is preliminary, no confirmatory RCTs
Clinical evidence
Limited clinical evidence. Longevity/anti-aging claims rest on animal data and small human pilots, not robust RCTs.
NIH Fact Sheet