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Supplement

Bacillus clausii

Evidence

Moderate
Evidence: 3 of 5 (Moderate)

What the evidence says

A spore-forming probiotic (recently reclassified as Alkalihalobacillus/Heyndrickxia clausii). The Enterogermina strains have RCTs and meta-analytic support for acute and antibiotic-associated diarrhea, especially in children; CSI08 and AO1125 have supportive GI/safety RCT data.

Moderate: RCT/meta-analytic support for diarrhea (specific strains).

Top Bacillus clausii supplements

About Bacillus clausii

A spore-forming probiotic (recently reclassified as Alkalihalobacillus/Heyndrickxia clausii). The Enterogermina strains have RCTs and meta-analytic support for acute and antibiotic-associated diarrhea, especially in children; CSI08 and AO1125 have supportive GI/safety RCT data. Strain-specific.

What Bacillus clausii supports

  • Moderate evidence for diarrhea, including antibiotic-associated
  • Spore form is acid- and shelf-stable

How much Bacillus clausii to take

The RDA prevents deficiency. The effective range is what clinical trials used to actually move the outcome.

Effective

16

billion_cfu

Enterogermina RCTs use ~2-6 billion spores/day. Often presence-only in blends; nominal range.

Clinical evidence

Moderate clinical evidence. Moderate: RCT/meta-analytic support for diarrhea (specific strains).

NIH Fact Sheet