KPV Tripeptide

A C-terminal tripeptide fragment (Lys-Pro-Val) of alpha-melanocyte-stimulating hormone (alpha-MSH). Animal and in-vitro studies show anti-inflammatory effects in colitis models via NF-kB inhibition. Marketed for gut inflammation and IBD support. Zero human RCTs exist for any route of administration. Oral bioavailability is uncharacterized — as a tripeptide it may survive gastric digestion better than larger peptides, but no human pharmacokinetic data exists.