About Ornithine
Non-proteinogenic amino acid involved in the urea cycle. Supplementation supports ammonia detoxification during prolonged exercise and has been studied for sleep quality and stress reduction. Often paired with L-arginine for nitric oxide support.
What Ornithine supports
- May improve sleep quality and reduce stress-related fatigue
- Supports ammonia clearance during prolonged exercise
How much Ornithine to take
The RDA prevents deficiency. The effective range is what clinical trials used to actually move the outcome.
Effective
400–2000
mg
400 mg before bed studied for sleep quality; 2–6 g studied for ammonia clearance and exercise fatigue. Higher doses (6g+) may cause GI distress.
Clinical evidence
Moderate clinical evidence. Small RCTs show improved sleep quality at 400mg and reduced exercise fatigue at higher doses; evidence is promising but limited in size
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