About Naringin
A grapefruit flavanone glycoside (aglycone naringenin) with antioxidant activity in preclinical work. Notable as a CYP3A4 and OATP inhibitor — the source of grapefruit-drug interactions. Human supplement evidence is limited and largely mechanistic.
What Naringin supports
- Citrus flavonoid with antioxidant activity
How much Naringin to take
The RDA prevents deficiency. The effective range is what clinical trials used to actually move the outcome.
Effective
100–500
mg
Citrus flavonoid; supplement amounts vary widely. Human efficacy dosing not established.
Clinical evidence
Limited clinical evidence. Largely mechanistic; clinically relevant mainly for drug-interaction potential
Examine.com