About Oxaloacetate
A Krebs-cycle intermediate marketed for metabolic and longevity support. A small trial in chronic fatigue (ME/CFS) reported reduced fatigue, but evidence is preliminary and largely from the supplement's manufacturer. Human efficacy is not established.
What Oxaloacetate supports
- Krebs-cycle intermediate studied for fatigue
How much Oxaloacetate to take
The RDA prevents deficiency. The effective range is what clinical trials used to actually move the outcome.
Effective
100–1000
mg
Studied at 100-1,000 mg/day (e.g. fatigue/longevity products use ~100-1,000 mg).
Clinical evidence
Limited clinical evidence. One small manufacturer-linked fatigue trial; evidence preliminary
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